Open AccessDIABETIC NEPHROPATHY
Author(s) -
Hassan Bukhari,
A. Shaukat,
Amir Hayyat Mahes
Publication year - 2016
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2016.23.03.1478
Subject(s) - medicine , urine , creatinine , diabetic nephropathy , urinary system , morning , urology , cross sectional study , gold standard (test) , pathology , kidney
Objectives: To determine diagnostic accuracy of spot urine Protein to creatinineratio for detection of diabetic nephropathy taking 24-hour urinary protein as gold standard.Study Design: cross sectional. Settings: Medical and Radiology department of Allied hospitalFaisalabad. Duration: 12-12-2013 to 12-06-2014. Sample size: 134. Material & Methods: Itwas a cross-sectional study done in Medical Unit I, Allied Hospital Faisalabad. 134 patients withsuspicion of diabetic nephropathy were included. 24-hour urine sample collected by instructingpatients to begin collection immediately after completion of first voiding in morning and tocollect all urine into same container having 5mL of 10% thymol in iso-propanol as a preservativefor 24-hours. This was thoroughly mixed, 2mL was taken for evaluation of proteins. P.C ratiowas calculated by dividing Urinary Protein concentration by Urinary Creatinine concentration.Results: The mean age of patients was noted as 55.11±6.79 years. There were 62.7% maleand 37.3% female patients. Mean PC ratio of the patients was noted as 0.21±0.07. Sensitivityof PC ratio was noted as 95.2%, whereas specificity was 76.5%, PPV 86.8%, NPV 90.7% withdiagnostic accuracy of 88.1%. Conclusion: The study results showed that PC