SUBFERTILE PATIENTS

Objective: To determine the efficacy of Letrozole as a first line drug in subfertile patients in term of pregnancy rate. Study Design: Case series study. Setting: OutpatientDepartment of Gynecology, Nishtar Hospital Multan. Period: May 2012 to December 2012.Material and methods: A total of 246 females with primary subfertility were enrolled in studyfrom gynecological outpatient department. Results: Mean age of the patients was 25.92 ±3.93years. 132 patients (54.0 %) had BMI of 2-25 kg/m2 and 101 patients (41%) had increasedof BMI 26-30 kg/m2 and 13patients (5%) were obese and had BMI of >30 kg/m2. 42 patients(17%) were illiterate. 54 patients (22%) were primary to middle and 62(25%) were matricand 88(36%) were FSC and > than FSC. 39(16%) patients had monthly income 10,000 and120(49%) patients had monthly income 10,000 -30,000 and 87(35%) patients had monthlyincome >30,000. Pregnancy was seen in 34% (83 patients). Conclusion: Aromatase inhibitors,Letrozole significantly increases pregnancy rate as a primary treatment in subfertility patients.