Open AccessSUBCLINICAL HYPOTHYROIDISM;
Author(s) -
Mohammad Asif,
Aziz Ullah,
Muhammad Akram
Publication year - 2012
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2013.20.01.621
Subject(s) - subclinical infection , medicine , kidney disease , population , renal function , dialysis , endocrine system , abnormality , gastroenterology , endocrinology , hormone , environmental health , psychiatry
Chronic kidney disease (CKD) is characterized by progressive destruction of renal mass with irreversible sclerosis andloss of nephrons.Various metabolic, hematological and endocrine abnormalities are known to occur in CKD. Subclinical hypothyroidismis an important endocrine abnormality associated with a greater cardiovascular risk, atherosclerosis and an important factor forprogression of renal disease in such patients. Objective: To calculate the frequency of subclinical hypothyroidism in predialysis CKDpatients. Design: Cross sectional survey. Setting: Pathology Department Post Graduate Medical Institute, Lahore. Period: 06 months(June 2011 to Dec 2011). Results: 210 patients were included in the study. Serum creatinine. TSH and FT4 were measured and therelevant data was entered in predesigned proforma. 19.5 % of CKD population had subclinical hypothyroidism with slightly increasedpreponderance in females as compared to males and also increased frequency as the stage of CKD increased. Subclinicalhypothyroidism is more common in CKD population. Conclusions: Increased frequency of subclinical hypothyroidism was found inpatients with reduced renal function not on dialysis. 19.5% of CKD population on conservative management had labortary evidence ofthyroid dysfunction.