METHANOLIC EXTRACT

Purpose of Study: The aim of this study is to look at the plant based such compounds that are known to have hepatoprotectivepotential. With above perspective, the study has been planned to see the hepatoprotective potential. To see hepatoprotective effect on theenzyme levels and histopathology. With the help of this study, some new hepatoprotective compound may be discovered which will help indeveloping an effective medicine. Material & Methods: The extract of Melia azedarch’s flower was screened for hepato protective effect. Albinorats were administered with carbon tetra chloride (CCl4) for inducing liver damage. Results: The effect of the extract was evaluated bymeasuring the liver enzymes like SGPT, Alkaline Phosphatase, Bilirubin and Gamma-GT in the serum. In the extract treated animals, there wassignificant decrease in liver enzyme levels. This observation leads to the conclusion that Melia flower extract possesses hepato protectiveactivity. The hepato protective activity of the methanolic extract was compared with standard Poly herbal formulation named Jigrine CL.Conclusion: In our study, we found the extract of Melia Azedarach (Flowers) has strong hepatoprotective activity.