Open AccessCHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM
Author(s) -
Haji Khan Khoharo,
Fatima Qureshi,
Shuaib Ansari,
Rizwan Javed
Publication year - 2010
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2010.17.01.2079
Subject(s) - chloroquine , plasmodium falciparum , medicine , malaria , drug resistance , pharmacology , immunology , biology , genetics
Objective: The study was conducted to determine the frequency of Chloroquine-resistant Plasmodium falciparum. Subjects& Methods: This was a descriptive case series study conducted at Muhammad Medical College Mirpurkhas & Liaquat University HospitalHyderabad/ Jamshoro, from January 2007 to December 2007. Total 160 patients with acute attack of fever were selected & studied who fulfilledthe inclusion criteria. The WHO extended test was done by giving 25 mg/kg body weight of Chloroquine base over 3 days. The interpretationof the test was done as per criteria laid down by WHO. Results: Out of one hundred sixty, 110 (68.75%) were males and 50 (31.25%) werefemales with ratio of 2.2:1. The age range 16-45 years with mean 28±12 years. Seventy one patients (44.375%) were Chloroquine sensitive.Chloroquine-resistance (CQR) Rl, Rll & both Rl Rll noted were 28.125%, 15.645% & 43.75% respectively. The CQR- R III was not observedin our study. Conclusions: In view of this situation, more organized and thorough studies must be conducted to elucidate the epidemiology,geographic-distribution & degree of Chloroquine resistance. And the local strategies be made to overcome this problem and to assess the needfor changing the first line drug.