Open AccessCOLORECTAL CANCER
Author(s) -
Muhammad Akram,
Javaid Iqbal,
Wasim Amer
Publication year - 2009
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2009.16.04.2570
Subject(s) - medicine , colorectal cancer , proportional hazards model , univariate analysis , rectum , stage (stratigraphy) , gastroenterology , epidemiology , survival analysis , t stage , cancer , oncology , multivariate analysis , paleontology , biology
There is paucity of data on epidemiology and survival in colorectal cancer from developing countries. O b j e c t i v e s : To determineoverall survival and its predictive factors. S e t t i n g : Department of Oncology Jinnah Hospital Lahore. P e r i o d : From July 1997 to Dec2007.Methods: 73 patients were analyzed. Patient demographic data including age, sex, socio-economic status, pre-treatment CEA levels,Duke's stage, site of tumor (colon, rectum) and complete tumor resectability were recorded. Univariate analysis by chi-square and multivariateanalysis were performed by Cox Regression Model to evaluate the predictors of survival. SPSS v 13.0 was used for statistical analysis. Kaplan-Meier estimate was used to calculate survival. R e s u l t s : Median age of our patients was 45 years. Male to female ratio was 1:1.2. Completesurgical resection could be performed in only 48 (68.5%) patients. Majority (70%) patients had Duke C and D. Overall survivals at 36 monthswas 53 % and was 90% for Duke A and B, while it was 61% and 26% for Duke's C and D respectively. Females had a better survival rate of74% as compared to males with a survival of 36%. Patients with proximal colon tumors had survival of 73% as compared to 37% in rectal/rectosigmoidgroup. Patients with high pre-treatment CEA had poor survival 39%. Only 25% patients with unresectable tumors were alive at 36months compared to 67% in patients with resectable tumors. Conclusion: Significant predictive factors for improved survival were female gender,early disease, patients with proximal colon tumors, low pre-treatment CEA levels and complete tumor resection.