Open AccessANAL FISSURE;
Author(s) -
Azeem Hashmat,
Tahira Ishfaq
Publication year - 2008
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2008.15.04.2943
Subject(s) - medicine , anal fissure , surgery , clinical trial , treatment modality , prospective cohort study
Objective: To evaluate the efficacy of glyceryl trinitrate (GTN) preparation for the treatment fissure in-ano. Design: This studyis a prospective clinical trial. Place and duration: this was conducted initially at PMC Faisalabad and other centers from November 2001 toonward for the period of five years. Patients and Methods: Out of 306 patients, 42 disliked/ refused this modality of treatment and waslaunched on 264 patients. 114 patients never followed up so, were excluded from the study. The remaining 276 patients applied 0.2% glyceryltrinitrate preparation on their anal verge thrice a day for two months. The patients were followed up at 1 to 12 weeks. The extent of st thimprovement in the presenting symptoms, side effects and complications were noted on questionnaires. Results: A healing rate of 64.3%, andrecurrence occurred in 35.7 %. 72 patients demanded surgery after failure/ non-compliance of GTN ointment treatment. Conclusion: glyceryltrinitrate preparation is a safe and effective modality for the treatment of fissure in-ano.