Open AccessHEAD INJURY;
Author(s) -
Muhammad Rafique Cheema,
Muhammad Aqueel Ashraf
Publication year - 2008
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2008.15.04.2853
Subject(s) - medicine , partial thromboplastin time , prothrombin time , complication , fibrinolysis , traumatic brain injury , head injury , incidence (geometry) , surgery , fibrin , anesthesia , coagulation , physics , optics , psychiatry , immunology
. Back Ground: Abnormal coagulation and fibrinolysis is a complication observed in individuals having traumatic brain injury.Objectives: To evaluate the incidence of this complication. Design: Retrospective and comparative study. Setting: Lahore general HospitalLahore. Period: From 1995 to 2000. Materials & Methods: One hundred adults, both male and female, having traumatic brain injury, admittedin Lahore general Hospital Lahore were subjected to estimation of prothrombin time, activated partial thromboplastin time and fibrin degradationproducts 48 hours after injury. Results: Fifty control and thirty three patients with severe head injury were studied. Prothrombin time in 17patients was prolonged. Which was statistically significant. APTT was prolonged in four cases when compared with normal. FDP were increasedin 51% cases. This elevation was again significant statistically. Conclusion: Significant changes in prothrombin time and fibrin degradationproducts were observed after 48 hours of brain injury.