Open AccessSERUM AND TISSUE MUCOPROTEINS AND SIALIC ACID IN THYROID DISEASES
Author(s) -
Zarfar Iqbal,
Tasneem Zafar
Publication year - 2008
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2008.15.03.2823
Subject(s) - goiter , medicine , mucoproteins , thyroid , endocrinology , sialic acid , hormone , thyroglobulin , thyroxine binding globulin , triiodothyronine , biochemistry , chemistry
. Objective: To find the correlation coefficient of serum mucoproteins and sialic acid to thyroid tissuein thyroid diseases. Study Design: The study was carried out at J.P.M.C, Karachi. Materials and Methods: A total oftwenty four thyroid patients and twenty normal subjects were studied. The cases were divided into non toxic goiterfourteen, and toxic goiter ten on the basis of clinical and physical examination, thyroid scanning and hormone analysis.Thyroid hormones were estimated in serum. Mucoproteins and sialic acid were estimated in serum as well as in thyroidtissue. Results: Estimations of thyroid hormones and thyroxine binding globulin (T.B.G.) are useful clinically to evaluatethe functions status and diagnosis of different thyroid disorders. Thyroid tissue is mainly composed of glycoprotein,thyroglobulin, and different studies showed that serum glycoprotein fractions varied in different thyroid diseases.Si 4gnificantly increased levels of T were observed in toxic goiter group. The levels of TBG was significantly increased4in non toxic goiter, toxic goiter patients while T /TBG ratio was significantly decreased in non toxic goiter. Coefficientcorrelation ( r) of serum to tissue mucoproteins shows an inverse relationship in non toxic goiter and toxic goiter patients.In non toxic goiter and toxic goiter patients the serum sialic acid levels to tissue sialic acid levels also shows an inverserelationship. Conclusion: Correlation coefficient analysis showed an inverse relationship of serum mucoproteins andsialic acid to thyroid tissue. It signifies that carbohydrate moieties are increased in the blood when the tissue arehyperactive and in the pathological state. It further concludes that thyrotoxic state might be converted into nodular formeven into cancerous form later on.