Open AccessEFFECTS OF VERAPAMIL ON CENTRAL & PERIPHERAL AIRWAY FUNCTION OF GUINEA PIGS
Author(s) -
Syed Saud Hasan,
Aftab Turabi,
Shaheen Sharaf Shah,
Muhammad Yousuf Salat,
Mahboob Ahmed Wagan
Publication year - 2006
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2006.13.04.4917
Subject(s) - verapamil , medicine , ovalbumin , bronchoconstriction , peripheral , airway , inhibitory postsynaptic potential , parenchyma , pharmacology , lung , guinea pig , immunology , calcium , antigen , anesthesia , pathology
Calcium ions play an important patho-physiological role inallergic reactions. It is therefore likely, Ca++ antagonist, Verapamil may modify the allergic broncho-pulmunaryresponses. Isolated preparations were used to examine the direct action of the Verapamil on bronchial and pulmonarysmooth muscles. Material and Methods: The bronchial spirals and the lung parenchymal strips were prepared thatenabled the investigation of the action of agents on peripheral and central airways in the same species and comparethe responses. To observe the effects on ovalbumin sensitized guinea pigs bronchial and lung parenchymal tissue after10 minutes exposure of verapamil in different concentration and to evaluate the antagonistic / inhibitory effect onantigen induced contractile responses. Results: The data showed that inhibition of antigen induced response withverapamil was better in central airways than to peripheral airways smooth muscle. Conclusion: Concluded from thisstudy that verapamil can influence both central and peripheral airway function by modulating antigen induced bronchoconstriction;however, it leaves query regarding the importance of this activity in clinical set up.