POLYCYSTIC KIDNEY DISEASE

Objectives: (1) To document various clinical presentation of disease. (2) To assess family members.(3) To audit our experience of management of this disease. Study Design: Prospective study. Period: 01-01-2001to 31-12-2004. Material & Methods: All patients presented with ADPKD were included in the study. Detailed history,clinical examination was performed in each case. Pain was managed by NSAIDS and USG was done in each case.Urinary tract infection was treated with antibiotics according to culture sensitivity. Blood pressure was managed by ACEinhibitors. Stones were treated with URS, ±DJ stents and ESWL. Patients with ESRD were offered renal replacementtherapy in the form of haemodialysis and renal transplant. Results: Total number of patients was 19. Male 10 and 9Female. Age ranges from 32-65 years. Pain abdomen and flank was main presenting complaint in 95% patients. Fever& renal stones were present in 10(53%) and 08(42%) of patients respectively. Extra renal manifestations were presentin 02(11%) of patients. 06 patients progressed to ESRD. 03 patients died due to ESRD. Parents of 04 patients hadADPKD. Majority 10(52%) could not be evaluated. 06 Patients (21%) had their sisters and brothers involved withADPKD. DJ Stenting and ESWL was the only surgical management done. Conclusion: ADPKD is hereditary disorder.No cure is possible. Management of this disease by medication and surgery only slows the progress of renal failure.Counseling should be done to avoid cousin marriage in affected families. Chromosome analysis facilities should beavailable to affected families free of cost for early detection of disease.