ACUTE MYOCARDIAL INFARCTION

Objectives: To determine the frequency of elevated homocysteine level inpatients presenting with acute myocardial infarction. Design: Cross-sectional. Place andDuration: Coronary Care Unit of Allied hospital Faisalabad, from 25-11-09- to 24-05-2010.Material and Methods: A total of 164 patients fulfilling the inclusion criteria were selected.Demographic details, history and examination findings of the patients were recorded. Bloodsample were collected in fasting state for estimation of plasma glucose, serum LDL, serumcholesterol and serum total homocysteine level. Data Analysis: Descriptive statistics like meanwith standard deviation were applied on age. Frequency of elevated homocysteine levels wascalculated in acute myocardial infarction with other conventional risk factors for coronary arterydisease. Male to female ratio was calculated. Frequency of elevated homocysteine levels wascalculated in acute myocardial infarction. Results: Out of 164, 53.9% (n=88) were male patientsand 76 46.08% (n=76) were females. Average age was 60.90±10.19. Among conventionalrisk factors, the frequency of elevated homocysteine levels was high (82%) in smokers. Thefrequency of elevated homocysteine levels was 55% in acute myocardial infarction and it was61% in males and 39% in females respectively. The frequency of elevated homocysteine levelswas highest (73%) among age group between 40-50 years. Conclusion: Frequency of elevatedhomocysteine levels was high among the patients with acute myocardial infarction. Moderateelevated homocysteine levels were associated with smoking.