Open AccessHOW MUCH CAN WE TRUST ON THE SELFREPORTED COLOR WHEN EVALUATING BREAST CANCER ANCESTRY
Author(s) -
René Aloísio da Costa Vieira,
Débora Sant’Anna de Andrade e Silva,
Ana Carolina Laus,
Carlos E. Bacchi,
René Julias Costa e Silva,
Idam de OliveiraJunior,
Rui Pereira,
Rui Manuel Reis
Publication year - 2021
Publication title -
mastology
Language(s) - English
Resource type - Conference proceedings
eISSN - 2594-5408
pISSN - 2594-5394
DOI - 10.29289/259453942021v31s2016
Subject(s) - genetic genealogy , bonferroni correction , demography , race (biology) , white (mutation) , breast cancer , ancestry informative marker , eye color , biology , genetics , indel , medicine , cancer , allele frequency , genotype , statistics , gene , mathematics , single nucleotide polymorphism , population , botany , sociology
Objective: To evaluate the association between self-reported color and ancestry in Brazilian patients with breast cancer (BC). Methods: Ethics approval 1136/2016. This was an observational, transversal, epidemiological study, evaluating 1,215 patients with BC. DNA was extracted to evaluate ancestry. For genetic ancestry, a 46 AIM-INDEL panel was used, and the polymerase chain reaction (PCR) products were subjected to capillary electrophoresis. The ancestral profile was evaluated with Structure v.2.3.3 software, for ancestry proportion, the percentages of ancestry in the different self-referred colors. For this purpose, descriptive statistics was performed (mean ± standard deviation [minimum − maximum]). To assess differences between groups, ANOVA and Bonferroni were used. Results: The color distribution was 77.9% (946) white, 17.4% (212) brown, 4.1% (50) black, 0.3% (4) yellow, and 0.2% (3) mixed. Genetically, the African ancestry proportion was significantly (p <0.001) higher in yellow (0.48 ± 0.51 [0.04–0.93]) with less difference between the other groups. Finally, the Amerindian ancestry proportion frequency was less frequent in all groups, and cafuse patients did not express differences between all race groups. Brown race group presented differences in the African and European Ancestry. Conclusion: Although we found many similarities between white color — European ancestry, black color — African ancestry, and yellow color — Asian ancestry, there is great miscegenation between patients and although they can be labeled as having one color, they do present many ancestral genes that would allow their inclusion in another race group.