Open AccessHereditary breast cancer – what we have learned in the last decade
Author(s) -
Renata Mendes de Freitas,
Pedro Henrique de Oliveira Medeiros,
Maximiliano Ribeiro Guerra,
Maria Teresa Bustamante-Teixeira
Publication year - 2021
Publication title -
mastology
Language(s) - English
Resource type - Journals
eISSN - 2594-5408
pISSN - 2594-5394
DOI - 10.29289/2594539420210041
Subject(s) - penetrance , breast cancer , genetic counseling , clinical practice , medicine , genetic testing , cancer , health professionals , population , health care , family medicine , genetics , gene , biology , political science , environmental health , law , phenotype
This literature review aims to inform and assist physicians and other health professionals in managing all information related to hereditary breast cancer, which is in constant and rapid growth, allowing for improvement in patient care and assistance. In addition, we seek to better identify which patients are eligible for the clinical criteria of association with risk of hereditary breast cancer, based on international recommendations and highlighting the main high and moderate penetrance genes that make up the multigenic panels for germline investigation in breast cancer, as well as the possibilities of clinical management that must be considered when complex decisions are required in clinical practice. Nowadays, there is more interest in population screening, in a greater supply of genetic tests, more genes included in multigene panels — allowing the search for genetic counseling —, apart from the need for clinical-decision support.