Open AccessAnti-allergic Activity of 70% Ethanol Extract of Strawberries in Ovalbumin Induced Male Mice
Author(s) -
Siska Siska,
Diene Roufiani,
Ema Dewanti
Publication year - 2020
Publication title -
jurnal jamu indonesia
Language(s) - English
Resource type - Journals
eISSN - 2407-7763
pISSN - 2407-7178
DOI - 10.29244/jji.v5i3.167
Subject(s) - ovalbumin , cetirizine , chemistry , anaphylaxis , ethanol , antioxidant , traditional medicine , pharmacology , food science , allergy , medicine , immunology , immune system , biochemistry
Anaphylaxis is the most common allergic reaction triggered by allergens such as insect poisons, food, and drugs through skin contact, injection, or inhalation. In vitro previous research showed that strawberries fruit have activity as antioxidant, anticancer, anti-inflammation, and anti-allergic. The research aimed to determine the antianaphylaxis strawberry fruit extract in mice (Balb/C strain) with ovalbumin-induced. Twenty-four Balb/C strain mice were divided into six groups (n=4). Group I and II as a normal and control group. Group III till VI as a treatment group was given cetirizine dose 0.042 mg/20 g BW and strawberry extract doses 0,68; 1,36; and 2,72 mg/20 g BW, respectively. This research showed that 70 % of ethanol extract of strawberries fruit have antiallergic activity in response to active cutaneous anaphylaxis. 70% ethanol extract of strawberries doses 2.72 mg/20 g BW had similar antiallergic activity compare with cetirizine. The conclusion of this study showed that strawberries fruit extract could be developed as an alternative medicine to anti-anaphylaxis or anti-allergic.