Cytotoxic Activity of Citral from Cymbopogon nardus as Anticancer of MCM-B2 Cell | Zendy

Hasim Hasim | Zendy; Surya Pangidoan Nasution | Zendy; Silvi Octavia Kurniawati | Zendy; Indah Rachmawati | Zendy

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Cytotoxic Activity of Citral from Cymbopogon nardus as Anticancer of MCM-B2 Cell

Author(s) -

Hasim Hasim,

Surya Pangidoan Nasution,

Silvi Octavia Kurniawati,

Indah Rachmawati

Publication year - 2020

Publication title -

current biochemistry

Language(s) - English

Resource type - Journals

eISSN - 2355-7877

pISSN - 2355-7931

DOI - 10.29244/cb.7.1.4

Subject(s) - geraniol , citral , mcf 7 , essential oil , breast cancer , ic50 , chemistry , cytotoxic t cell , cancer cell , traditional medicine , cancer , food science , medicine , biochemistry , in vitro , human breast

Cancer is a deadly disease caused by cell abnormalities characterized by uncontrolled cell growth. One type of cancer that is the second leading cause of death is breast cancer. Lemongrass (Cymbopogon nardus) is a plant containing citral and geraniol which has the potential as an anticancer. This research was aimed to analyze the potential of essential oils from citronella as antiproliferation of MCM-B2 breast cancer cells. The results of this research showed that lemongrass essential oil was able to significantly reduce the growth of MCM-B2 cancer cells (p<0.05). The concentration of 3 ppm showed an significant difference in doxorubicin, and the concentration of 24 ppm had the highest inhibitory activity with an IC50 value of 5.38 ppm. Keywords: Antiproliferation, breast cancer, MCM-B2, essential oils, fragrant lemongrass

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