Open AccessCytotoxic Activity of Citral from Cymbopogon nardus as Anticancer of MCM-B2 Cell
Author(s) -
Hasim Hasim,
Surya Pangidoan Nasution,
Silvi Octavia Kurniawati,
Indah Rachmawati
Publication year - 2020
Publication title -
current biochemistry
Language(s) - English
Resource type - Journals
eISSN - 2355-7877
pISSN - 2355-7931
DOI - 10.29244/cb.7.1.4
Subject(s) - geraniol , citral , mcf 7 , essential oil , breast cancer , ic50 , chemistry , cytotoxic t cell , cancer cell , traditional medicine , cancer , food science , medicine , biochemistry , in vitro , human breast
Cancer is a deadly disease caused by cell abnormalities characterized by uncontrolled cell growth. One type of cancer that is the second leading cause of death is breast cancer. Lemongrass (Cymbopogon nardus) is a plant containing citral and geraniol which has the potential as an anticancer. This research was aimed to analyze the potential of essential oils from citronella as antiproliferation of MCM-B2 breast cancer cells. The results of this research showed that lemongrass essential oil was able to significantly reduce the growth of MCM-B2 cancer cells (p<0.05). The concentration of 3 ppm showed an significant difference in doxorubicin, and the concentration of 24 ppm had the highest inhibitory activity with an IC50 value of 5.38 ppm.
Keywords: Antiproliferation, breast cancer, MCM-B2, essential oils, fragrant lemongrass