Open AccessExperimental model for assessing the readiness of the wound surface to accept skin grafts
Author(s) -
А. А. Бакунович,
Ju. V. Yarashenka,
Е. Ф. Радута,
E. V. Koov,
Vyacheslav Buko,
A. A. Astrowski
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2021-18-3-340-350
Subject(s) - quercetin , wound healing , contraction (grammar) , pharmacology , chemistry , surgery , biomedical engineering , medicine , biochemistry , antioxidant
The aim of the study, performed on 65 Wistar rats, was to develop a new model and, as an example, use it to identify the extent to which quercetin and the quercetin-2-hydroxypropyl-β-cyclodextrin nanocomplex, applied to the wound, affect the engraftment of skin autografts. Grafts were obtained from the ear shells of animals, and graft’s survival rate was assessed by the degree of inhibition of wound contraction. It is shown that the latter depends on the area of grafts and the time after which they were located on the wound surface after its creation. It was shown that quercetin worsens, and quercetin-2- hydroxypropyl-β-cyclodextrin does not impair the ability of the wound surface to accept the graft.