Open AccessStudy of the effect of some drugs used in the clinic on the AQP1 activity of the human erythrocyte membrane
Author(s) -
K. V. Basiakova,
Э. П. Титовец
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2021-18-2-204-211
Subject(s) - erythrocyte membrane , pharmacology , membrane , chemistry , aquaporin , biophysics , medicine , biology , biochemistry
Using the stopped flow method and based on the study of the intensity of light scattering, the effect of pharmacological preparations used in the clinic on the water exchange of human erythrocytes, catalyzed by aquaporin AQP1, was studied. Pharmacological preparations used in therapeutic concentrations have a variable inhibitory effect on water permeability of the erythrocyte membrane. The obtained results broaden our understanding of the molecular action mechanism of the investigated drugs. In view of the wide distribution of AQP1 in various human tissues, these data should be taken into account when carrying out therapeutic measures aimed at normalizing the water exchange of organs and tissues.