Open AccessDetermination of the parathyroid hormone reference interval in patients with different stages of the chronic kidney disease
Author(s) -
Natalia Karlovich,
О. С. Спиридонова,
Е. Г. Сазонова,
Т. В. Мохорт
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 1
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2021-18-2-186-195
Subject(s) - secondary hyperparathyroidism , medicine , kidney disease , parathyroid hormone , hyperparathyroidism , population , urology , dialysis , bone remodeling , endocrinology , bone mineral , gastroenterology , osteoporosis , calcium , environmental health
Secondary hyperparathyroidism (SHPT) is one of the most clinically significant complications of chronic kidney disease (CKD) due to associated mineral, bone disorders, and metastatic calcification. The indicators of mineral and bone metabolism of 635 patients with different CKD stages and 50 persons of the control group were analyzed using a neural network algorithm and the mathematical technology BootStrаp, which allowed determining the target PTH intervals for each stage in patients with CKD, corresponding to the optimal indicators of mineral density and metabolism bone tissue, in order to improve the survival of this category of patients. It was found that the upper limit of the reference interval of the PTH level in patients with CKD and GFR > 35 ml/min coincides with the general population, in patients with CKD and GFR 15‒35 ml/min it is 185 pg/ml, which is 3 times higher than in the general population, and in patients with CKD and GFR 1500 pg/ml determines the extreme risk of developing severe SHPT complications.