Open AccessMorphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells
Author(s) -
С.П. Рубникович,
Sergey Sirak,
Ю.Л. Денисова,
В. А. Андреева,
Е.В. Кузьменко,
Т. Э. Владимирская,
I. Khomich,
И. Д. Волотовский
Publication year - 2020
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 1
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2020-17-4-444-451
Subject(s) - mesenchymal stem cell , adipose tissue , regeneration (biology) , pathology , bone tissue , medicine , microbiology and biotechnology , biology
The article presents the analysis of the morphological changes of the periodontal tissues of laboratory animals using mesenchymal stem cells (MSCs). The goal of the study is to create a model of experimental periodontitis and to identify the characteristics of morphological changes in the periodontal tissues using a biomedical cell product based on the allogeneic adipose tissue of MSCs (AT MSCs). The application of a mixture of AT MSCs and osteoinduced AT MSCs (in the ratio of 1:1) allows reducing the time of bone defect regeneration in comparison to that of bone tissue regeneration when AT MSCs and osteoinduced AT MSCs are used separately, which is expressed in the filling of the bone defect with a fibroreticular osteogenic tissue, as well as with a muscle tissue one month after surgery. In 2 months, in the defect area filled with a collagen membrane with a mixture of AT MSCs and osteoinduced AT MSCs, the initial signs of the formation of trabecula of bones were detected, which is evident of a more comprehensive osteosynthesis process compared to the blood clot use.