Open AccessDiagnostic significance of biomarkers of the epileptic seizures development in patients with arterial aneurysms
Author(s) -
Н. И. Нечипуренко,
Р. Р. Сидорович,
И. Д. Пашковская,
И.И. Степанова,
О. Л. Змачинская,
Т. А. Прокопенко
Publication year - 2019
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 1
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2019-16-3-324-331
Subject(s) - medicine , epilepsy , gastroenterology , clinical significance , epileptic seizure , catalase , thiobarbituric acid , pathology , oxidative stress , psychiatry , lipid peroxidation
The aim of the study was to establish the diagnostic significance of biochemical parameters, considered as markers of epileptic seizures in patients with arterial aneurysms (AA). 82 patients with AA (50.4 ± 11.5 year-old) with epileptic seizures (35 persons) and without them (47 persons) were examined. Before treatment, the following biochemical parameters were determined in plasma of patients: lactate, pyruvate, products reacting with thiobarbituric acid (TBA-P), antioxidant activity of the serum, activity of superoxidedismutase and catalase, tumor necrosis factor-alpha (TNF-ά). To characterize the diagnostic significance of the results, the diagnostic sensitivity and the diagnostic efficacy were determined. The complex of biochemical tests with high diagnostic significance, consisting of lactate, lactate/pyruvateindex, catalase activity, TBA-P and TNF-α, was established in patients with AA with epileptic seizures. It allows considering these parameters as markers of epileptic seizures development in patients with AA. Among the most diagnostically significant tests for detection of epileptic seizures in patients with AA should be considered the concentration of TNF-ά with diagnostic sensitivity of 73%, the diagnostic specificity of 79% and the diagnostic efficacy of 75%.