Open AccessMechanisms of damage of acinar pancreatic cells in acute alcohol pancreatitis
Author(s) -
Л. А. Можейко
Publication year - 2019
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ medycynskìh navuk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 1
eISSN - 2524-2350
pISSN - 1814-6023
DOI - 10.29235/1814-6023-2019-16-1-108-116
Subject(s) - trypsinogen , acute pancreatitis , intracellular , autophagy , cytosol , zymogen , pancreatitis , mitochondrion , chemistry , acinar cell , medicine , endocrinology , microbiology and biotechnology , biochemistry , biology , enzyme , apoptosis , trypsin
The review analyzes the current data on the main mechanisms of toxic effects of alcohol and its metabolites on pancreatic acinar cells in acute pancreatitis. It is shown that the mechanisms of cellular damage are multicomponent and closely linked by the regulatory factors of the molecular level. At the early stage of the disease, they lead to the following structural and functional changes in acinar cells that promote the premature intracellular trypsinogen activation and autoaggression: sustained rise of cytosolic Ca2+ and excess of mitochondrial matrix Ca2+; destabilization due to lysosomes and zymogen granules; debective autophagy; mitochondrial depolarization; decreased ATP production and necrosis.