Open AccessSynthesis and study of the effect of arginine-vasopressin (6-9) analogue on the behavior of rats of different ages
Author(s) -
К. В. Бородина,
А. А. Стаханова,
В. П. Мартинович,
О.Г. Воскресенская,
В. П. Голубович,
А. А. Каменский
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2021-57-1-61-69
Subject(s) - vasopressin , arginine , nasal administration , stimulus (psychology) , endocrinology , medicine , psychology , chemistry , pharmacology , developmental psychology , amino acid , biochemistry , psychotherapist
The article presents the synthesis and results of the study of the effect of chronic neonatal administration by intranasal method of an analogue of the C-terminal fragment of arginine-vasopressin (AVP) - N -Ac- D Met-Pro-Arg-Gly-NH 2 on the training and level of depression in white rats of three age groups. It is shown that the most significant effect of the analogue was manifested in the test for the development of conditional reaction of active avoidance. A favorable effect on the degree of depression of animals is also well expressed. According to the data obtained, we conclude that the action of the peptide is manifested only under the influence of a biologically significant stimulus.