Open AccessPeg derivatives for the synthesis of water-soluble cyanine dye Cy5
Author(s) -
Т. П. Северинчик,
Dmitrii V. Tsavlovskii,
О. Л. Шарко,
Vadim V. Shmanai
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2021-57-1-41-47
Subject(s) - cyanine , reagent , ethylene glycol , polymer , chemistry , peg ratio , ether , substrate (aquarium) , polyvinyl alcohol , combinatorial chemistry , fluorescence , organic chemistry , polymer chemistry , physics , oceanography , finance , quantum mechanics , economics , geology
An effective method for the preparation of water-soluble cyanine dye Cy5 using the soluble polymers supported liquid-phase organic synthesis (LPOS) was proposed. Poly (ethylene glycol) methyl ether with a molecular weight of 2000 was used as a polymer substrate, which allowed us to simplify the characterization of products at intermediate stages of synthesis by NMR spectroscopy. This approach makes it easy to obtain the necessary cyanine dyes, which are widely used as fluorescent labels and are popular modifying reagents in biochemistry and medicine.