Open AccessSynthesis of acylic derivatives of prolylleucylglycinamide
Author(s) -
V. А. Haidukevich,
С. К. Петкевич,
E. G. Karankevich,
П. В. Курман,
З. И. Куваева,
В. И. Поткин,
В. А. Книжников
Publication year - 2019
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2019-55-4-429-435
Subject(s) - chemistry , formic acid , amide , benzoic acid , acetic anhydride , organic chemistry , ammonia , glycine , acylation , base (topology) , acetic acid , chloride , medicinal chemistry , amino acid , catalysis , mathematical analysis , biochemistry , mathematics
Tert-butyloxycarbonylprolylleucylglycinamide is obtained both by the interaction of tert-butyloxycarbonylprol ylleucylglycine ethyl ester with a methanolic ammonia solution and by the reaction of glycine amide with a mixed anhydride which was synthesized from tert-butyloxycarbonylprolylleucine and isobutylchloroformate. The removal of the tert-butyloxycarbonyl group by the action of formic acid or a dioxane solution of hydrogen chloride and treatment of the resulting salts with the corresponding base yielded a prolylleucylglycinamide, by the interaction of which with acetic, benzoic or 5-phenylisoxazole-3-carboxylic acids chlorides acyl derivatives of prolylleucylglycinamide are obtained.