Open AccessАn improved method for preparation of heptyl (4-trifluoroacetyl) benzoate
Author(s) -
П. В. Сенин,
Л. С. Станишевский,
Yauhen B. Akayeu
Publication year - 2019
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2019-55-2-171-174
Subject(s) - acylation , reagent , yield (engineering) , toluene , benzoyl chloride , chloride , chemistry , aluminium chloride , organic chemistry , combinatorial chemistry , grignard reagent , aluminium , materials science , catalysis , metallurgy
A convenient three-step method for synthesis of heptyl (4-triuoroacetyl)benzoate, an important neutral anion carrier, has been developed. The key step of the method is acylation of toluene by triuoroacetic anhydride in presence of aluminium chloride at –8 – –10 o C. The procedure gives high overall yield and, unlike the earlier methods, does not include any organometallic reagents, therefore allowing scaling it up to several hundred grams, that makes the target compound much more readily available.