Open AccessProtein-ligand interactions of CYP51 Candida glabrata and human CYP11В1 with 7-substituted 19-nortestosterones
Author(s) -
Tatsiana Shkel,
Irina Grabovec,
А. А. Гилеп,
Tatsiana Varaksa,
Natallia Strushkevich,
В. И. Долгопалец,
Yu. G. Charnou
Publication year - 2019
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2018-54-4-450-454
Subject(s) - pyrazine , candida glabrata , chemistry , pyridine , stereochemistry , ligand (biochemistry) , monooxygenase , androstane , medicinal chemistry , biochemistry , antifungal , microbiology and biotechnology , cytochrome p450 , biology , receptor , metabolism
The interaction of human monooxygenases and pathogenic fungi with previously obtained esters of isomeric 7-methyl-19-nor-testosterones and a number of heteroaromatic acids – derivatives of pyridine and pyrazine, was studied. Interaction with the active center of CYP11B1 derivatives of steroids of the androstane series containing methyl group at C7 and residues of heteroaromatic acids at C17β is shown.