Open AccessLONG-LIVED RADIONUCLIDES IN THE PRODUCTION OF [18F]FLUOROCHOLINE FOR PET-DIAGNOSIS
Author(s) -
P. V. Tylets,
O. V. Tugay,
В. О. Крот,
A. A. Ivaniykovich,
S. A. Soroka,
Д. И. Бринкевич,
С. Д. Бринкевич,
Oleg Baranovski,
Г. В. Чиж
Publication year - 2018
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2018-54-3-359-368
Subject(s) - nuclide , radionuclide , decay product , radiochemistry , chemistry , environmental science , nuclear physics , radon , physics
In the present study the distribution of long-lived radionuclides between the drug product, recovered water [ 18O]H2 O and solid phase extraction cartridges was studied in [18F]fluorocholine production process. Isotopic composition for long-lived nuclides (half-lives = 10–312 days) was determined, the mechanisms of their formation and accumulation on cartridges are considered. It was shown that in the batches of pharmaceutical produced the content of long-lived nuclides is by 5 orders of magnitude lower than the limit value specified by the appropriate 07/2016:2793 European Pharmacopoeia article. The results obtained are of vital importance for optimization of the procedures for radioactive waste management in the production of [18F]fluorocholine using IBA Cyclone 18/9 HC cyclotron and, consequently, for minimization of radiation exposure of personnel.