Open AccessSYNTHESIS OF NEW 6-N-SUBSTITUTED PURINE NUCLEOSIDES
Author(s) -
Т. И. Кулак,
D. V. Yankovskaya,
A. V. Konoplich,
T. N. Buravskaya,
Еle. Kalinichenko
Publication year - 2018
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ hìmìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-2342
pISSN - 1561-8331
DOI - 10.29235/1561-8331-2018-54-3-305-313
Subject(s) - pyrrolidine , purine , chemistry , moiety , amination , stereochemistry , acetylation , organic chemistry , biochemistry , enzyme , catalysis , gene
New derivatives of purine nucleosides containing the residues of N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine in 6-position of heterobase have been synthesized. The one-step preparation of 6-N-substituted nucleosides was performed in good yields by the amination of 6-Cl-derivatives of O-acetylated purine nucleosides and concomitant deacylation of OH-groups of a carbohydrate moiety with N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine.