Open AccessEffects of adipose-derived mesenchymal stem cells on nociceptive sensitivity and repair processes at achilles tendon injury model in rats
Author(s) -
А.-М. В. Ерофеева,
И. П. Жаворонок,
Olga Antipova,
Е. Л. Рыжковская,
Tatiana Kuznetsova,
И. Б. Василевич,
С. В. Пинчук,
И. Д. Волотовский,
А. Ю. Молчанова
Publication year - 2020
Publication title -
doklady nacionalʹnoj akademii nauk belarusi
Language(s) - English
Resource type - Journals
eISSN - 2524-2431
pISSN - 1561-8323
DOI - 10.29235/1561-8323-2020-64-5-574-582
Subject(s) - mesenchymal stem cell , transplantation , medicine , adipose tissue , granulation tissue , neovascularization , achilles tendon , tendon , edema , regeneration (biology) , angiogenesis , lesion , inflammation , nociception , stem cell , pathology , surgery , wound healing , biology , microbiology and biotechnology , receptor
On the model of Achilles tendon injury in rats, the antinociceptive and regenerative effect of allogeneic transplantation of various doses of adipose-derived mesenchymal stem cells (ADMSCs) into the lesion area was studied. It was found that netiher of tested regimens of allogeneic transplantation of ADMSCs contributed to a decrease in the edema of the injured limb. Among the studied regimens, only a twofold administration of 0.25 • 10 6 ADMSCs exhibited an antinociceptive effect. Administration of 0.50 • 10 6 ADMSCs promoted the accelerated onset of neovascularization of tendon tissue, while enhancing inflammation and the formation of granulation tissue. Double transplantation of 0.25 • 10 6 ADMSCs led to accelerated reorganization of collagen fibers, later neovascularization, however, there was an absence of inflammatory infiltrate, lipomatosis, and massive formation of granulation tissue in the lesion area.