Open AccessOne-pot synthesis of cyclic β-dicarbonyl compounds as synthons for 11-deoxyprostanoids
Author(s) -
Ф. С. Пашковский,
Ю. С. Донцу,
Д. И. Корнеев,
Д. Б. Рубинов,
Ф. А. Лахвич
Publication year - 2020
Publication title -
doklady nacionalʹnoj akademii nauk belarusi
Language(s) - English
Resource type - Journals
eISSN - 2524-2431
pISSN - 1561-8323
DOI - 10.29235/1561-8323-2020-64-2-186-192
Subject(s) - synthon , cyclopentane , chemistry , cyclopentenone , alkyl , stereochemistry , organic chemistry
One-pot synthesis of cyclic β-dicarbonyl synthons for 11-deoxyprostanoids has been developed on the basis of cyclopentane-1,3-dione and 5-phenyl tetronic acid. The obtained 2-alkyl(arylalkyl)-substituted cyclopentane-1,3-diones have been transformed into cyclopentenone precursors of 11-deoxy-PGE 1 and 11-deoxy-PGE 2 analogues.