Open AccessUse of hemostatic drug Spongostan as a carrier of mesenchymal stem cells in the treatment of experimental urinary incontinence in rats
Author(s) -
С. В. Пинчук,
А. Ю. Молчанова,
И. Б. Василевич,
И. П. Жаворонок,
Е. И. Пехтерева,
Olga Antipova,
И. В. Залуцкий,
И. Д. Волотовский
Publication year - 2019
Publication title -
doklady nacionalʹnoj akademii nauk belarusi
Language(s) - English
Resource type - Journals
eISSN - 2524-2431
pISSN - 1561-8323
DOI - 10.29235/1561-8323-2019-63-4-457-465
Subject(s) - mesenchymal stem cell , urinary system , saline , urinary incontinence , urology , medicine , materials science , pathology
The adhesion and proliferation of rat adipose-derived mesenchymal stem cells (MSCs) as part of biocomposite with haemostatic drug Spongostan Absorbable Haemostatic Gelatin Powder as well as its regenerative efficiency after its introduction into the periurethral region in rats with experimental urinary incontinence were studied. It was found that MSCs rapidly adhere to the surface of the carrier and actively proliferate. The periurethral injection of biocomposite (Spongostan + MSCs) quickly and eectively recovers the urine continence function in animals that have undergone modeling of incontinence by urethrolysis. Spongostan hydrated in the ratio of 1 :24 inphosphate-saline buer has a volume-forming eect in the urethra of experimental animals.