Open AccessSynthons for new 11-deoxy-3-oxa-3,7-inter-m-phenylene prostaglandin analogues
Author(s) -
Ф. С. Пашковский,
Д. И. Корнеев,
Ф. А. Лахвич
Publication year - 2019
Publication title -
doklady nacionalʹnoj akademii nauk belarusi
Language(s) - English
Resource type - Journals
eISSN - 2524-2431
pISSN - 1561-8323
DOI - 10.29235/1561-8323-2019-63-3-291-297
Subject(s) - synthon , cyclopentane , chemistry , knoevenagel condensation , phenylene , cyclopentenone , prostaglandin , stereochemistry , acetic acid , organic chemistry , biochemistry , polymer , catalysis
A synthetic scheme for obtaining cyclopentenone synthons for metabolically stable 11-deoxy-3-oxa-3,7-inter- m -phenylene prostaglandin analogues has been developed. The key step of the scheme is the Knoevenagel condensation of cyclopentane-1,3-dione with the readily available 3-(formylphenoxy)acetic acid methyl ester in the presence of Hantzsh ester.