Open AccessSYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1,4- AND 1,4,5-SUBSTITUTED-1H-1,2,3TRIAZOLES IN RELATION TO THE STAPHYLOCOCCUS AUREUS STRAIN
Author(s) -
Alexander V. Zuraev,
А. В. Лишай,
Ю. В. Григорьев,
Олег А. Ивашкевич
Publication year - 2018
Publication title -
doklady nacionalʹnoj akademii nauk belarusi
Language(s) - English
Resource type - Journals
eISSN - 2524-2431
pISSN - 1561-8323
DOI - 10.29235/1561-8323-2018-62-3-293-297
Subject(s) - staphylococcus aureus , antibacterial activity , cefotaxime , strain (injury) , chemistry , cycloaddition , staphylococcus , antibiotics , combinatorial chemistry , bacteria , catalysis , microbiology and biotechnology , organic chemistry , biology , biochemistry , genetics , anatomy
A number of 1,4- and 1,4,5-triazoles have been synthesized using a modified catalytic system for the Huisgen [3+2] cycloaddition reaction. The bactericidal activity of the synthesized compounds has been studied. The synthesized derivatives of 1H-1,2,3-triazoles have demonstrated higher antibacterial activities in relation to the pathogen Staphylococcus aureus strain which can be comparable with the clinically used antibiotic “Cefotaxime”.