Open AccessLithium-induced modiphication of the physicochemical state of membrane proteins and lipids in human erythrocytes
Author(s) -
G. P. Zubritskaya,
Е. И. Слобожанина
Publication year - 2021
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ bìâlagìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-230X
pISSN - 1029-8940
DOI - 10.29235/1029-8940-2021-66-3-295-301
Subject(s) - microviscosity , membrane , chemistry , lithium (medication) , lipid bilayer , membrane protein , in vitro , red blood cell , cell membrane , phosphatidylinositol , biophysics , membrane lipids , membrane fluidity , biochemistry , biology , endocrinology , kinase
The effect of various concentrations of lithium sulfate on human erythrocytes in vitro has been studied. It has been shown that the effect of lithium salt in maximum pharmacological and toxic concentrations on cells leads to a modification of the physicochemical state of membrane-bound proteins and lipids. It was found that in human erythrocytes exposed to lithium ions, there is a decrease in the activity of membrane-bound acetylcholinesterase and methgemoglobin reductase, as well as a change in the microviscosity of the lipid bilayer of membranes. The results obtained can be used to create a cell test system for assessing the toxicity of lithium compounds.