Open AccessEpigenetic control of differentiation of mesenchymal stem cells. Stem cells differentiation in liver
Author(s) -
I. D. Volotovski,
Д. А. Ермоленко,
N. I. Harokhava
Publication year - 2020
Publication title -
vescì nacyânalʹnaj akadèmìì navuk belarusì. seryâ bìâlagìčnyh navuk
Language(s) - English
Resource type - Journals
eISSN - 2524-230X
pISSN - 1029-8940
DOI - 10.29235/1029-8940-2020-65-1-106-118
Subject(s) - epigenetics , biology , dna methylation , mesenchymal stem cell , epigenetic regulation of neurogenesis , stem cell , cellular differentiation , microbiology and biotechnology , histone , microrna , genetics , dna , histone methyltransferase , gene expression , gene
The recent data on epigenetic control of differentiation in mesenchymal stem cells to be the background of embryogenesis and regeneration process in organism are considered. Epigenetic control is bases on three intramolecular mechanisms – DNA methylation, structural modification of histone proteins and microRNA active on posttranscription and posttranslation levels. As an example, the issues of stem cell differentiation in the liver are considered.