Open AccessShort-term moderate caloric restriction in a high-fat diet alleviates obesity via AMPK/SIRT1 signaling in white adipocytes and liver
Author(s) -
Shaohong Zhang,
Shuoshuo Sun,
Wei Xiao,
Mengxiao Zhang,
Yu Chen,
Xiaodong Mao,
Guofang Chen,
Chao Liu
Publication year - 2022
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.29219/fnr.v66.7909
Subject(s) - medicine , endocrinology , white adipose tissue , ampk , sirtuin 1 , steatosis , adipose tissue , amp activated protein kinase , chemistry , biology , protein kinase a , phosphorylation , downregulation and upregulation , biochemistry , gene
Obesity is a growing problem for public health worldwide. Calorie restriction (CR) is a safety and effective life intervention to defend against obesity. Short-term moderate CR may be a more favorable strategy against this pathology. However, the mechanisms behind the effects of CR remain to be clarified. Increased energy expenditure in the liver and brown adipose tissue could potentially be manipulated to modulate and improve metabolism in obesity. Moreover, nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1) and AMP-activated protein kinase (AMPK) are well-characterized metabolic modulators. We aim to explore the anti-obesity effects of short-term moderate CR by improving energy metabolism via the SIRT1/AMPK pathway in white adipocytes and liver in a mouse model of obesity.