Open AccessNobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates G1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of JEG-3 and BeWo via regulating the p53 signaling pathway
Author(s) -
Mengling Zhang,
Jian Liu,
Rui Zhang,
Zengenni Liang,
Shenghua Ding,
Huanling Yu,
Yang Shan
Publication year - 2021
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.29219/fnr.v65.5649
Subject(s) - apoptosis , annexin , propidium iodide , cell cycle , microbiology and biotechnology , biology , nobiletin , viability assay , flow cytometry , trophoblast , western blot , chemistry , programmed cell death , biochemistry , placenta , fetus , pregnancy , genetics , flavonoid , gene , antioxidant
Hypoxia is associated with abnormal cell apoptosis in trophoblast cells, which causes fetal growth restriction and related placental pathologies. Few effective methods for the prevention and treatment of placenta-related diseases exist. Natural products and functional foods have always been a rich source of potential anti-apoptotic drugs. Nobiletin (NOB), a hexamethoxyflavonoid derived from the citrus pomace, shows an anti-apoptotic activity, which is a non-toxic constituent of dietary phytochemicals approved by the Food and Drug Administration. However, their effects on hypoxia-induced human trophoblast cells have not been fully studied.