Open AccessAntidiabetic effects of a lipophilic extract obtained from flowers of Wisteria sinensis by activating Akt/GLUT4 and Akt/GSK3β
Author(s) -
Yibing Lv,
Wei Ren,
Yirui Zhang,
Yun Huang,
Hao Jiang,
Kun Ma,
Yankai Ma,
Xinzhou Yang
Publication year - 2020
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.29219/fnr.v64.3589
Subject(s) - glut4 , protein kinase b , insulin resistance , glucose transporter , medicine , endocrinology , steatosis , skeletal muscle , in vivo , glucose uptake , gsk 3 , insulin , streptozotocin , diabetes mellitus , pharmacology , chemistry , biology , phosphorylation , biochemistry , microbiology and biotechnology
Type 2 diabetes mellitus is primarily caused by insulin resistance (IR) in insulin-sensitive tissues, including liver, white adipose tissues (WAT), and skeletal muscles. Discovering nutritious foods with antidiabetic effects is of great significance. Numerous published reports indicated that protein kinase B (Akt) and glucose transporter 4 (GLUT4) play crucial roles in ameliorating IR and diabetic symptoms.