Open AccessPreparation, Characterization of A New Cis – Iodoplatin and Cis - Carboplatin Complexes and Study There Spectral, Physical and Pharmaceutical Properties
Author(s) -
Jasim M. Abdul Hussein,
Saadon A. Owda,
Samaá M. Hassan
Publication year - 2019
Publication title -
maǧallaẗ ǧāmiʿaẗ bābil/maǧallaẗ ǧāmiʻaẗ bābil
Language(s) - English
Resource type - Journals
eISSN - 2312-8135
pISSN - 1992-0652
DOI - 10.29196/jubpas.v27i1.2086
Subject(s) - carboplatin , molar conductivity , chemistry , salicylic acid , fourier transform infrared spectroscopy , molar ratio , nuclear chemistry , characterization (materials science) , conductivity , medicinal chemistry , stereochemistry , organic chemistry , elemental analysis , materials science , nanotechnology , chemical engineering , catalysis , biochemistry , biology , genetics , chemotherapy , cisplatin , engineering
This search includes preparation of new cis–platin, in the form of iodin, and new two cis - carboplatin complexes {cis [Pt(4-aminoantipyrine) (NH3)2]I2 and cis[Pt (aminosalicylicacid) (NH3)2]I}, which used as anti - cancer drugs, they are prepared by using the organic ligands 4-amino salicylic acid and 4-amino anti pyrine. These complexes were characterized by using UV–Vis., FTIR, XRD and 1HNMR spectroscopic techniques . The effect of the concentration and the temperature on the molar electrical conductivity of its solutions were studied. The expiry date (half-life) for the solutions of the complexes in the circumstances at the degrees (350C) and (20 0C) was determined