Open AccessMICROSATELLITE INSTABILITY TESTING'S BENEFITS IN A VARIETY OF CANCERS
Author(s) -
Rafah S. Almuttairi,
Shaymaa Abd Al-jasim Al Shukri Afaf K. Shwaikh
Publication year - 2021
Publication title -
indian journal of medical research and pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 2349-5340
DOI - 10.29121/ijmrps.v8.i8.2021.1
Subject(s) - microsatellite instability , microsatellite , biology , genetics , genome , computational biology , genome instability , dna mismatch repair , genetic testing , dna , gene , dna damage , dna repair , allele
The accumulation of mutations across the genome, notably in microsatellite (MS) DNA repeat sequences, is a hallmark of MSI/dMMR tumors. Microsatellite instability (MSI) is a genetic change in which microsatellites, which typically have one to six nucleotide repetitions, acquire mutations corresponding to small nucleotide deletions or insertions. Immunohistochemistry or a PCR-based test directed against a set of five MS areas were used to create an MSI detection method. MSI is a significant biomarker for cancer diagnosis, prognosis, and treatment options.