Open AccessBIOINFORMATICS ANALYSIS OF GENES ASSOCITED WITH TYPE 2 DIABETES MELLITUS
Author(s) -
Shruti Mishra,
Sarva Jit Singh,
Rajeev Mishra,
Prashant Ankur Jain,
Ritusha Mishra,
Vivek Mishra
Publication year - 2017
Publication title -
international journal of research - granthaalayah
Language(s) - English
Resource type - Journals
eISSN - 2394-3629
pISSN - 2350-0530
DOI - 10.29121/granthaalayah.v5.i7.2017.2118
Subject(s) - tcf7l2 , biology , genetics , gene , genome wide association study , wnt signaling pathway , kegg , single nucleotide polymorphism , population , computational biology , bioinformatics , medicine , gene expression , genotype , transcriptome , environmental health
Type 2 Diabetes mellitus is a multi-factorial disease caused due to gene defect as well as environmental factor. GWAS have played a primary role in demonstrating that genetic variation in a number of loci, SNPs, affects the risk of T2DM. there are our objective is to find out Disease pathway map by taking all genes of T2DM which are 35 in numbers and but in all there are 10 mostly involve in T2Dm from all over world population and it is find out by GWAS method then after we analyzed the KEGG pathway by analyzing T2DM pathway, Insulin signaling pathway, and WNT signalling pathway to find out common protein then after by bioinformatics analysis combined and expend these pathways toward common protein for understanding the Diseases mechanism. We do Protein-protein interaction and find out their complete target hub protein and target prediction for network hub. so for all these analysis I collect the total genes involve in T2DM and take those gene which are common for all population and their SNPs ,chromosome location in these all genes and by using string database I tried to find out the target protein hub which are found in this disease so there I have taken 5 most frequent genes and doing PPI in human so there are all have their own target protein hub-KCNJ11 have target protein hub PPKACA & TCF7L2 have complete target protein hub TLEI & PPARG have a target protein hub EP300 & CDKL1 have compete target protein hub UCB & HHEX complete target protein SOX2.