Open AccessIN VITRO ANTI – INFLAMMATORY ACTIVITY OF THE FLOWERS OF NERIUM OLEANDER (WHITE)
Author(s) -
S. Jasmine Mary,
B. Chithra,
S. Sivajiganesan
Publication year - 2017
Publication title -
international journal of research - granthaalayah
Language(s) - English
Resource type - Journals
eISSN - 2394-3629
pISSN - 2350-0530
DOI - 10.29121/granthaalayah.v5.i6.2017.2005
Subject(s) - inflammation , anti inflammatory , diclofenac sodium , pharmacology , drug , traditional medicine , medicine , diclofenac , natural product , in vitro , arthritis , chemistry , immunology , biochemistry
Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. In this present study anti-inflammatory potential of Nerium Oleander was investigated. Based on the resulted the ethonolic extract of the flowers showed the highest anti inflammatory activity. The increments in absorbance of test samples with respect to control indicated stabilization of protein i.e. inhibition of heat-induced protein (albumin) denaturation by Nerium oleander and reference drug diclofenac sodium.