Open AccessAssociation Association of genetic variant of OXTR (rs53576) and MTNR-1B (rs10830963 and rs1387153) with symptoms of stress in Pakistani women with Gestational Diabetes.
Author(s) -
Fatima Abid,
Sadaf Ahmed,
Syeda Sadia Fatima,
Shamoon Noushad
Publication year - 2021
Publication title -
international journal of endorsing health science research
Language(s) - English
Resource type - Journals
eISSN - 2310-3841
pISSN - 2307-3748
DOI - 10.29052/ijehsr.v9.i3.2021.420-425
Subject(s) - gestational diabetes , single nucleotide polymorphism , candidate gene , medicine , pregnancy , type 2 diabetes , etiology , genetic association , disease , bioinformatics , diabetes mellitus , genetics , genotype , biology , gene , gestation , endocrinology
Background: Pregnancy continues to be an event full of risks, complications and adverse outcomes for women despite advanced clinical and diagnostic methods and treatment options available in medicine. Diabetes, as a multifactorial and complex disease, is a possible outcome of a blend of numerous genetic variants of differing scarcities. The exact etiology of gestational diabetes mellitus (GDM) is unclear; however, the interaction of genetic and environmental factors, especially the genetic variants identified as the genetic loci for type 2 diabetes as candidate genes for GDM.
Methodology: It will be a case-control study with a genetic analysis of single nucleotide polymorphisms (SNPs) of candidate genes expressed using real-time PCR with sequencing. The study will also evaluate the primer sequence of SNPs.
Discussion: We will be able to share the findings after the completion of our research. The results of this study will able helpful in addressing the psycho-physiological needs of women with GDM, which may also be used to devise strategies to benefit the sustainable long-term behavioural change following the affected pregnancy.