Open AccessCompilation of a database, specific for the pesticide active substance and their metabolites, comprising the main genotoxicity endpoints
Author(s) -
Metruccio Francesca,
Castelli Ilaria,
Civitella Consuelo,
Galbusera Carmen,
Galimberti Francesco,
Tosti Luca,
Moretto Angelo
Publication year - 2017
Publication title -
efsa supporting publications
Language(s) - English
Resource type - Journals
ISSN - 2397-8325
DOI - 10.2903/sp.efsa.2017.en-1229
Subject(s) - medicine , pesticide , public health , environmental health , biology , agronomy , nursing
In 2014, EFSA has commissioned the compilation of a database specific for the pesticide residues including active substances and their metabolites, which comprises different genotoxicity endpoints, i.e. point mutations, structural and numerical chromosome aberrations, and DNA damage.Data collection on individual genotoxicity studies has been retrieved from regulatory toxicological reports (Draft or Renewal Assessment Reports, i.e. DARs or RARs, respectively) as provided by the Rapporteur Member State (RMS) during the pesticide peer review process at European Level. The final EFSA conclusion on the overall genotoxic potential of active substance or metabolites taking into account all available information is not included in the database. The database contains identity and genotoxicity information on more than 290 active substances and some of their metabolites.The database represents a practical tool to complement in-silico tools i.e. QSAR (Quantitative structure–activity relationship models), grouping and read across for prediction of the genotoxicity hazard of the pesticides residues, and it supposes to enlarge the chemical domains for their application