Open AccessIdentifying and collecting relevant literature related to the oral toxicity of furan and its methyl analogues, 2‐methylfuran and 3‐methylfuran
Author(s) -
Nielsen Elsa,
Bredsdorff Lea,
Olesen Pelle Thonning,
Sharma Anoop Kumar,
Beltoft Vibe,
Nørby Karin
Publication year - 2017
Publication title -
efsa supporting publications
Language(s) - English
Resource type - Journals
ISSN - 2397-8325
DOI - 10.2903/sp.efsa.2017.en-1066
Subject(s) - furan , chemistry , toxicity , environmental chemistry , organic chemistry
An extensive literature search to identify and collect all relevant literature on the oral toxicity of furan and its methyl analogues, 2-methylfuran and 3-methylfuran was performed in the two databases PubMed and Web of Science for four Areas. The literature search resulted for Area 1 (toxicokinetics) in 1,674 hits from PubMed and 2,318 hits from Web of Science; for Area 2 (oral toxicity in experimental animals) in 2,329 hits from PubMed and 3,914 hits from Web of Science; for Area 3 (in vitro and in vivo genotoxicity and mode of action) in 1,100 hits from PubMed and 2,290 hits from Web of Science; and for Area 4 (observations in humans) in 639 hits from PubMed and 1,073 from Web of Science. After removal of the duplicates, the total number of hits for Area 1 was 3,184, for Area 2 was 4,883, for Area 3 was 2,588, and for Area 4 was 1,295. The evaluation of all retrieved references for relevance by screening the title and abstract (if available) and applying eligibility criteria (inclusion/exclusion) resulted in a total number of relevant references for Area 1 of 33, for Area 2 of 44, for Area 3 of 75 (including two relevant references located in the Area 2 literature search), and for Area 4 of 5. © European Food Safety Authority, 2017