Open AccessSafety and efficacy of a feed additive consisting of l ‐valine produced by Corynebacterium glutamicum CGMCC 7.366 for all animal species (Ningxia Eppen Biotech Co., Ltd.)
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Fašmon Durjava Mojca,
Kouba Maryline,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Ramos Fernando,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Cocconcelli Pier Sandro,
Glandorf Boet,
Prieto Maradona Miguel,
Saarela Maria,
Brozzi Rosella,
Pettenati Elisa,
TarrésCall Jordi
Publication year - 2021
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2021.6521
Subject(s) - corynebacterium glutamicum , valine , food science , fermentation , microbiology and biotechnology , animal feed , biology , feed additive , genetically modified organism , amino acid , chemistry , biochemistry , gene , broiler
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l ‐valine produced by fermentation using a non‐genetically modified strain of Corynebacterium glutamicum ( CGMCC 7.366). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety ( QPS ) approach to safety assessment. The FEEDAP Panel concludes that l ‐valine produced using C. glutamicum CGMCC 7.366 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species. The FEEDAP Panel has concerns on the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of l ‐valine produced using C. glutamicum CGMCC 7.366 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l ‐valine produced using C. glutamicum CGMCC 7.366 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The additive l ‐valine produced by fermentation using C. glutamicum CGMCC 7.366 is regarded as an efficacious source of the essential amino acid l ‐valine for non‐ruminant nutrition. For the supplemental l ‐valine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.