Open AccessSafety and efficacy of l ‐valine produced by fermentation using Corynebacterium glutamicum CGMCC 7.358 as a feed additive for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Fašmon Durjava Mojca,
Kouba Maryline,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Ramos Fernando,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Cocconcelli Pier Sandro,
Glandorf Boet,
Herman Lieve,
Maradona Miguel Prieto,
Saarela Maria,
Anguita Montserrat,
Holczknecht Orsolya,
Galobart Jaume,
Manini Paola,
Pettenati Elisa,
Pizzo Fabiola,
TarrésCall Jordi
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.6286
Subject(s) - valine , fermentation , feed additive , food science , animal feed , animal species , biology , corynebacterium , chemistry , biochemistry , bacteria , amino acid , zoology , genetics , broiler
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐valine produced by fermentation using a non‐genetically modified strain of Corynebacterium glutamicum ( CGMCC 7.358). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain meets the qualifications for the qualified presumption of safety ( QPS ) approach to safety assessment and is considered safe. l ‐Valine produced using C. glutamicum CGMCC 7.358 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species, for the consumer and for the environment. No conclusion could be drawn on the potential of l ‐valine produced using C. glutamicum CGMCC 7.358 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The product l ‐valine produced by fermentation using C. glutamicum CGMCC 7.358 is regarded as an efficacious source of the essential amino acid l ‐valine for non‐ruminant nutrition. For the supplemental l ‐valine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.