Open AccessStatement on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans
Author(s) -
HernandezJerez Antonio F,
Adriaanse Paulien,
Aldrich Annette,
Berny Philippe,
Coja Tamara,
Duquesne Sabine,
Marinovich Marina,
Millet Maurice,
Pelkonen Olavi,
Pieper Silvia,
Tiktak Aaldrik,
Topping Christopher J,
Wolterink Gerrit,
Herman Lieve,
Chiusolo Arianna,
Magrans José Oriol,
Widenfalk Anneli
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.6276
Subject(s) - pseudomonas chlororaphis , genotoxicity , metabolite , biology , european commission , toxicology , threshold dose , horticulture , microbiology and biotechnology , pseudomonas , european union , chemistry , toxicity , business , genetics , biochemistry , bacteria , economic policy , organic chemistry , endocrinology
The European Commission requested EFSA to provide scientific advice on the translocation potential by Pseudomonas chlororaphis MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3‐deepoxy‐2,3‐didehydro‐rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other P. chlororaphis strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species P. chlororaphis . It has been concluded that there is a potential for translocation of P. chlororaphis MA342 to edible plant parts following seed treatment till an estimated concentration up to about 10 5 cfu/g and some exposure can be assumed by consumption of fresh commodities. Also, production of the metabolite DDR in the plant cannot be excluded. Regarding levels of DDR in the raw agricultural commodities, exposure estimates based on the limit of quantification (LOQ) for DDR in cereals cannot be further refined while there is no information on the levels of DDR in peas in the dossier. As regards genotoxicity, DDR induced chromosomal damage; however, it was not possible to conclude whether it is through an aneugenic or clastogenic mechanism. Hence, it is not possible to draw a reliable conclusion that DDR is producing an aneugenic effect nor to determine a threshold dose for aneugenicity. Thus, it is not possible to revise the human risk assessment as regards exposure to DDR. The concerns identified in the EFSA conclusion of 2017 remain.