Open AccessSafety of l ‐tryptophan produced using Escherichia coli CGMCC 11674 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Ramos Fernando,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Anguita Montserrat,
Galobart Jaume,
Holczknecht Orsoylia,
Manini Paola,
Pettenati Elisa,
Pizzo Fabiola,
TarrésCall Jordi
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.6168
Subject(s) - european commission , tryptophan , animal species , animal feed , feed additive , escherichia coli , food science , microbiology and biotechnology , fermentation , food safety , chemistry , genetically modified organism , biology , european union , biochemistry , business , amino acid , zoology , broiler , gene , economic policy
Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐tryptophan produced by fermentation with Escherichia coli CGMCC 11674 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The FEEDAP Panel issued an opinion in 2019 in which they could not conclude on the safety of the additive for the target animals and for the consumer due to tryptophan‐related impurities such as 1,1′‐ethylidene‐bis‐ l ‐tryptophan ( EBT ). The applicant submitted additional data and the European Commission ( EC ) has requested EFSA to deliver a new opinion on the safety of the additive under assessment. The manufacturing process has been adjusted to reduce the amount of tryptophan‐related impurities and the analysis of three new batches of the additive indicated that levels of EBT and 1‐methyl‐1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid ( MTCA ) represent no safety concerns for the target species or for the consumer.